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Home / Research / Publications / The tumor microenvironment and immune infiltration landscape of KRAS mutant pancreatic ductal adenocarcinomas (PDAC) compared to colorectal adenocarcinomas (CRC)

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The tumor microenvironment and immune infiltration landscape of KRAS mutant pancreatic ductal adenocarcinomas (PDAC) compared to colorectal adenocarcinomas (CRC)

– Caris Life Sciences

Poster

Key Finding:

The tumor microenvironment of pancreatic ductal carcinomas harboring KRAS mutations shows similar patterns to that of KRAS mutant colorectal cancers and presents with immune-cold features. 

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  • Not all treated KRAS-mutant pancreatic adenocarcinomas are equal: KRAS G12D and survival outcome.

    – Caris Life Sciences

    Poster, Presentation

    Conclusions Patients with G12D mutations have significantly lower survival compared to G12R. Significant molecular differences were seen in MAPK pathway gene expression, markers of immune… […]

  • High gene expression levels of ARF6 are associated with the immune microenvironment and predict poor outcomes

    – Caris Life Sciences

    Poster

    Background: ADP-ribosylation factor 6 (ARF6) is a small GTPase in the RAS superfamily, which regulates membrane trafficking, remodeling and tumor progression. Preclinical study shows that TP53 and KRAS cooperatively activate… […]
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