Pan-cancer association between increased iron utilization and poor prognosis highlights potential of transferrin receptor-targeting therapies in multiple tumor types | Caris Life Sciences
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Pan-cancer association between increased iron utilization and poor prognosis highlights potential of transferrin receptor-targeting therapies in multiple tumor types

– Caris Life Sciences

Poster

Key Finding:

Except for vulvar squamous cell carcinoma, TFRC over-expression is associated with worse overall survival in 23 tumor types. 

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  • Pan-tumor survey of RET fusions as detected by next-generation RNA sequencing identified RET fusion positive colorectal carcinoma as a unique molecular subset

    – Caris Life Sciences

    Manuscript

    Highlights RET fusions are identified in 15 tumor types and carcinoma of unknown primary. Different dominant RET fusion variant within each tumor type: KIF5B-RET (NSCLC), NCOA4-RET (colorectal,… […]

  • Detection of NRG1 Gene Fusions in Solid Tumors

    – Caris Life Sciences

    Manuscript

    Abstract Purpose: NRG1 gene fusions are rare but potentially actionable oncogenic drivers that are present in some solid tumors. Details regarding the incidence of these… […]
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