Multi-omic profiling of metastatic lesions to guide treatment selection: The side out 2 trial experience | Caris Life Sciences
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Multi-omic profiling of metastatic lesions to guide treatment selection: The side out 2 trial experience

Study Primary Objective

The aim of this prospective pilot study was to explore if treatment selection based on Multi-omic Profiling (MoP) provides clinical benefits superior to empiric treatment selection in progressive metastatic breast cancers (MBC).

Conclusions

  • This study confirmed the unique role of MoP in selecting effective treatments for MBC.
  • This approach provided clinical benefits for 56% of previously treated MBC patients, which met the primary objective of the study.
  • This study also suggests that irinotecan may be an under-developed drug for MBC patients.
  • As such, this approach merits further investigation.

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