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Molecular profiling of HPV-positive and -negative HNSCC

– Caris Life Sciences

Poster

Background

Head and neck squamous cell carcinoma (HNSCC) is comprised of two subtypes: human papilloma virus (HPV)-and carcinogenic-associated (HPV-negative), both linked to inactivation of the TP53 pathway. We examined alterations in HPV positive (pos) and negative (neg) HNSCC to identify treatment options and elucidate differences in pathogenesis.

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  • Genomic and Molecular Profiling of Human Papillomavirus Associated Head and Neck Squamous Cell Carcinoma Treated with Immune Checkpoint Blockade Compared to Survival Outcomes

    – Caris Life Sciences

    Manuscript

    Simple Summary The prognosis of recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) remains poor. However, human papillomavirus (HPV)-associated oropharyngeal squamous cell… […]

  • Molecular profiling of head and neck squamous cell carcinoma

    – Caris Life Sciences

    Manuscript

    Background: Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of recurrence, and with few approved targeted agents, novel treatments are needed. We analyzed… […]
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