Background
- EWSR1::CREM (Ewing sarcoma breakpoint region 1::cAMP response element modulator) gene fusions are rare, occurring in a variety of tumors, including intracranial myxoid mesenchymal tumor, hyalinizing clear cell carcinoma of the head and neck, clear cell sarcoma, and angiomatoid fibrous histiocytoma.
- Our study expands the spectrum of EWSR1::CREMrearranged tumors, describing three cases of squamous cell carcinoma (SCC) of the thorax and head and neck that encode this gene fusion.