Introduction
- NRG1 has been explored as the target of emerging HER2/HER3-directed anti-cancer agents, and the recent discovery of NRG1 fusion events may have important therapeutic implications.
- While these fusions are relatively uncommon, they have been most thoroughly described in lung and pancreaticobiliary neoplasms.
- A recentstudybyGuptaetal. reported over 150NRG1fusion partners in a wide variety of tumor types.
- This study seeks to further characterize NRG1 fusions in ovarian, fallopian tube, and primary peritoneal carcinomas.