Age as a factor in the molecular landscape and the tumor-microenvironmental signature of osteosarcoma | Caris Life Sciences
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Age as a factor in the molecular landscape and the tumor-microenvironmental signature of osteosarcoma

– Caris Life Sciences

Poster

Key Finding:

A comparison of tumors from younger versus older osteosarcoma patients demonstrates differences in the mutational landscape and tumor microenvironment composition, including increased gene amplifications in younger patients and decreased B-cell abundance in older patients. 

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  • Biom-43. The genomic, transcriptomic, and epigenomic landscape of isocitrate dehydraogenase wild type glioblastoma across the age continuum

    – Caris Life Sciences

    Poster

    Abstract BACKGROUND Older age is a poor prognostic factor for glioblastoma (GBM) patients. We tested whether the intrinsic molecular landscape of the tumor may contribute… […]

  • Theranostic profiling for actionable aberrations in advanced high-risk osteosarcoma with aggressive biology reveals high molecular diversity: the human fingerprint hypothesis

    – Caris Life Sciences

    Manuscript

    Abstract The survival of patients with advanced osteosarcoma is poor with limited therapeutic options. There is an urgent need for new targeted therapies based on… […]
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