Key Finding:
The tumor microenvironment of pancreatic ductal carcinomas harboring KRAS mutations shows similar patterns to that of KRAS mutant colorectal cancers and presents with immune-cold features.
– Caris Life Sciences
Conclusions Patients with G12D mutations have significantly lower survival compared to G12R. Significant molecular differences were seen in MAPK pathway gene expression, markers of immune… […]
– Caris Life Sciences
Background: ADP-ribosylation factor 6 (ARF6) is a small GTPase in the RAS superfamily, which regulates membrane trafficking, remodeling and tumor progression. Preclinical study shows that TP53 and KRAS cooperatively activate… […]
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