The immune microenvironment of liver metastasis as a guide for immunotherapeutic potential in breast cancer

Authors:

Daniel Flores, Sofi Castanon, Joanne Xiu, Paula R. Pohlmann, Foluso Ademuyiwa, Elia Obeid, Neelmima Denluluri, Antoinette Tan, Jasgit Sachdev, Elisa K. Jackson, Lee Schwartzberg, W. Michael. Korn, and Evanthia T. Roussos Torres

Conclusions:

  • In our patient cohort, immune cells in the TME of liver metastatic sites were less abundant.
  • The paucity of immune cells suggests breast cancer metastases to the liver harbors a less immunogenic niche.
  • Increased TMB in all metastatic sites uncovers the heterogeneity among different tumor sites.
  • Immunosuppressive cells of myeloid and lymphoid origin prevent further immune cell infiltration in the TME.
  • Lack of PD-L1 expression among liver metastatic sites suggests another possible mechanism explaining the lack of response to ICIs in certain patients.
  • In our patient cohort, immune cells in the TME of liver metastatic sites were less abundant.
  • The paucity of immune cells suggests breast cancer metastases to the liver harbors a less immunogenic niche.
  • Increased TMB in all metastatic sites uncovers the heterogeneity among different tumor sites.
  • Immunosuppressive cells of myeloid and lymphoid origin prevent further immune cell infiltration in the TME.
  • Lack of PD-L1 expression among liver metastatic sites suggests another possible mechanism explaining the lack of response to ICIs in certain patients.

 

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