PI3K/PTEN/Akt/mTOR pathway aberrations and co-incidence of hormone receptors and HER2 in 19,784 diverse solid tumors | Caris Life Sciences
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PI3K/PTEN/Akt/mTOR pathway aberrations and co-incidence of hormone receptors and HER2 in 19,784 diverse solid tumors

– Caris Life Sciences

Poster

Background

Molecular aberrations in the phosphatidylinositol 3-kinase (PI3K) pathway have been documented across cancers, especially PIK3CA mutations and mutation or loss of PTEN. These alterations may be relevant to therapies targeting the PI3K/PTEN/Akt/mTOR signaling pathway.

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  • Prevalence of phosphatidylinositol-3-kinase (PI3K) pathway alterations and co-alteration of other markers in breast cancer

    – Caris Life Sciences

    Abstract

    Background: PI3K/AKT signaling pathway is often activated in breast cancer (BC), through mutations in PIK3CA or AKT1, and alterations in PTEN, thus promoting cell survival.… […]

  • PI3 Kinase Pathway Mutations in Human Cancers

    – Caris Life Sciences

    Manuscript

    International genome analysis studies have now cataloged mutations in thousands of human cancers. An assessment of these studies using cBioPortal1,2 and by Tamborero et al3 shows that… […]
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