Background / Aim of the project
•Novel treatment strategies are needed to improve survival for biliary tract cancers (BTC) (1).
•Polybromo-1 (PBRM1) is a tumor suppressor gene that is involved in chromatin remodeling (2).
•Preclinical studies suggest induction of synthetic lethality by PARP inhibitors in PBRM1-mutated renal cell carcinoma (3).
Aim of the project:
•To describe the molecular and immunological landscape of PBRM1-mutated biliary tract cancers.