Background:
- HPV is an infectious cause of several malignancies. Neuroendocrine neoplasms (NEN) are highly heterogeneous, ranging from lowgrade indolent tumors to high-grade clinically aggressive carcinomas.
- Aside from cervical NENs, most have not traditionally been associated with HPV, but our initial studies uncovered a subset of NENs that are HPV 16/18 positive.
- To identify actionable differences between HPV+ NEN and non-NENs, genomic and transcriptomic landscapes were investigated.