Background
- Aberrant Wnt/β-catenin activation has been implicated in tumor formation, progression in BTC.
- CTNNB1 is a key transcriptional co-activator in canonical Wnt signaling.
- The impact of CTNNB1 alterations on outcomes in intrahepatic (IHCC) vs extrahepatic (EHCC) vs gallbladder (GB) tumors and patterns of gene co-expression is unclear.
- We examined the molecular correlates and predictive and prognostic significance of CTNNB1 alterations in a real-world cohort of patients (pts) with BTC.