Angiogenic and T-effector Subgroups identified by Gene Expression Profiling (GEP) show propensities for PBRM1 and BAP1 alterations in Clear-Cell Renal Cell Carcinoma (ccRCC) | Caris Life Sciences
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Home / Research / Publications / Angiogenic and T-effector Subgroups identified by Gene Expression Profiling (GEP) show propensities for PBRM1 and BAP1 alterations in Clear-Cell Renal Cell Carcinoma (ccRCC)

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Angiogenic and T-effector Subgroups identified by Gene Expression Profiling (GEP) show propensities for PBRM1 and BAP1 alterations in Clear-Cell Renal Cell Carcinoma (ccRCC)

– Caris Life Sciences

Poster

Background:

Predictive biomarkers for optimal treatment selection in RCC are lacking. Gene expression data from
IMmotion151 and Javelin Renal 101 clinical trials generated anti-angiogenic and immune signatures that
warrant further validation. We aimed to describe the genomic and gene expression profiles in a multi-institutional database of patients with ccRCC, and its association with other biomarkers of interest.

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