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Comprehensive Molecular Profiling for Cancer

Physician Tests

Personalized Treatment Starts Here

Understanding cancer at the molecular level can lead to better treatment options. Caris molecular profiling includes whole exome and whole transcriptome sequencing of tissue and blood, plus protein analysis and other testing options for tissue specimens. Paired with molecular AI tools, Caris comprehensive molecular profiling is focused on helping cancer patients today and tomorrow.

Physician Services

Expert Scientific and Clinical Support

Caris healthcare provider services help put precision medicine into practice. Deep molecular insights enable physicians to navigate among therapies with potential benefit, identify therapies that may not have been considered, determine drugs unlikely to provide benefit (avoiding unnecessary toxicities and costs) and match patients to clinical trials.

High quality molecular information to guide precise
and individualized treatment decisions.

Molecular Profiling for Cancer Therapy Selection

Caris helps improve the lives of thousands of patients each day through the analysis of DNA and RNA by whole exome and whole transcriptome sequencing (WES/WTS) in tissue or blood, plus immunohistochemistry (IHC) of key proteins in tissue specimens. Caris also provides clinically validated AI algorithms to help with therapy selection in cases of metastatic colorectal cancer and cancer of unknown primary.

Tissue Profiling

Blood Profiling

Molecular AI

“Caris was built for one reason – to improve the human condition. Through tireless efforts, breakthrough molecular science and a passionate commitment to quality, we remain steadfastly focused on the most important part of our work – the patient.”

— David Dean Halbert, DSc (h.c.), Chairman, Founder and CEO

Driving Molecular Science Innovation

748,000+

Cases

6.5+ Million

Tests

38+ Billion

Molecular Markers Measured

I went from being told there were no additional treatment options to being healthy and able to spend more time with my family.

Patient, Edwin Asturizaga
Stage IV Lung Cancer Survivor

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Edwin Asturizaga, Stage IV Lung Cancer Survivor, Profiled by Caris

1,000,000+ Data Points per Patient

“Comprehensive” Genomic Profiling

com • pre • hen • sive
/ˌkämprəˈhensiv/ complete; including all or nearly all elements or aspects of something.

Caris defines Comprehensive Genomic Profiling with:

  • 23,000 DNA Genes
  • 61,000 RNA Transcripts
  • Protein Analysis

DNA

Whole Exome Sequencing
(SNVs, Indels & Copy Number Alterations)

RNA

Whole Transcriptome Sequencing
(Fusions, Gene Expression & Variant Transcripts)

Protein

Immunohistochemistry

Whole Slide Imaging/Tissue Slide Digital

Histopathology

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Be Sure with Caris Assure

Caris Assure™ is a minimally invasive blood test that utilizes circulating Nucleic Acid Sequencing (cNAS) to analyze cell-free DNA and RNA from plasma, plus genomic DNA and messenger RNA from circulating white blood cells (WBCs), to distinguish somatic tumor, incidental clonal hematopoiesis (CH) and incidental germline variants.

MI Profile Comprehensive Molecular Profiling

MI Profile™ comprehensive testing delivers whole exome sequencing (WES – DNA) and whole transcriptome sequencing (WTS – RNA) for 23,000+ genes, as well as protein analysis and AI-predictive algorithms. MI Profile is designed to reveal a complete molecular blueprint that can guide more precise and individualized treatment decisions and help improve patient outcomes.

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