Characterization of ESR1 mutations in Endometrial and Ovarian Cancers

Authors:

Stephanie Gaillard, Asnakech Bayable, Sachin Kumar Deshmukh, Utthara Nayar, Joanne Xiu, Lishann Ingram, Gretchen Hubbard, George Sledge, Thomas Herzog, Premal Thaker, Sharon Wu

Background

  • Lowgrade ovarian(OC) and endometrial(EC) cancers frequently express estrogen receptor (ERα,encodedbyESR1), and are considered hormonally responsive tumors.
  • The use of endocrine therapy in the advanced and recurrent disease setting is common.
  • Mechanisms for endocrine therapy failure in gynecologic cancers are not well understood.
  • In breast cancer, ESR1 mutations (ESR1mt) confer resistance to endocrine therapy.
  • In this study, we aim to evaluate the prevalence of ESRmt, and associated characteristics in OC and EC.
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