Characterizing outcomes of biliary tract cancers BTC with β-catenin CTNNB1 alterations

Authors:

Lydia D. Chow, Diana L. Hanna, Rituparna Ganguly, Yasmine Baca, Jonathan Pai, Ani Misirian, Sandra Algaze, Mehmet Akce, Philip Philip, Syma Iqbal, Rachna Shroff, Heinz Josef Lenz, Tanios Bekaii-Saab, Anthony El-Khoueiry

Background

  • Aberrant Wnt/β-catenin activation has been implicated in tumor formation, progression in BTC.
  • CTNNB1 is a key transcriptional co-activator in canonical Wnt signaling.
  • The impact of CTNNB1 alterations on outcomes in intrahepatic (IHCC) vs extrahepatic (EHCC) vs gallbladder (GB) tumors and patterns of gene co-expression is unclear.
  • We examined the molecular correlates and predictive and prognostic significance of CTNNB1 alterations in a real-world cohort of patients (pts) with BTC.
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