Conclusions:
- Real-word data show that high PIM1 expression correlates with poorer survival in clear cell RCC but not in papillary RCC.
- Poor survival in PIM1 high expressors appears independent of treatment received.
- PIM1 enrichment in metastatic clear cell RCC, and the identified DEGs, suggest that PIM1 influences the extracellular matrix to promote metastases in RCC.
- The correlation between PIM1 expression and IL-6 expression supports our data that an IL-6/JAK/STAT/PIM1 pathway is involved in clear cell RCC. Please see the companion poster at this conference: IL-6 signaling via JAK/STAT axis influences PIM1 expression in renal cell carcinoma. (K. Meza)