Molecular drivers of organotropism and cisplatin resistance in germ cell tumors | Caris Life Sciences
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Molecular drivers of organotropism and cisplatin resistance in germ cell tumors

Conclusions

  • There are no molecular alterations associated with site of metastasis: KIT mutations are more prevalent in primary tumors and TP53 mutations more prevalent in metastases
  • No recurrent alterations were associated with platinum-resistance
  • In chemotherapy-naïve tumors, significantly lower platinum sensitivity scores were associated with platinum-resistant alterations
  • Limitations of this study include the small sample size and lack of clinical follow-up
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