Association of Adaptive Immunity Inflammatory Genes with Survival in Prostate Cancer | Caris Life Sciences
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Association of Adaptive Immunity Inflammatory Genes with Survival in Prostate Cancer

Study Highlights

  • SELE and IL6 genes had a stronger association with FOSB in tumors biopsied from the primary as opposed to metastatic site.
  • A strong correlation is observed between immune check point genes and the TNF𝛼𝛼 across tumors biopsied at primary or metastatic sites.
  • High expression of ADAMTS4 is associated with better overall survival (OS) in the primary site but is associated with worse OS in the metastatic site.

Conclusions

  • We identified significant differences in the expression of inflammatory regulators and cytokines between localized and metastatic PCa tumors, which correlate with OS.
  • These changes in the immune microenvironment can be leveraged for rational immunotherapy development and better targeted approaches.
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