Study Highlights
- SELE and IL6 genes had a stronger association with FOSB in tumors biopsied from the primary as opposed to metastatic site.
- A strong correlation is observed between immune check point genes and the TNF𝛼𝛼 across tumors biopsied at primary or metastatic sites.
- High expression of ADAMTS4 is associated with better overall survival (OS) in the primary site but is associated with worse OS in the metastatic site.
Conclusions
- We identified significant differences in the expression of inflammatory regulators and cytokines between localized and metastatic PCa tumors, which correlate with OS.
- These changes in the immune microenvironment can be leveraged for rational immunotherapy development and better targeted approaches.