Comprehensive Molecular Mapping of Pancreatic Ductal Adenocarcinoma Relates XPO1 mRNA Expression Levels to Potential Clinical Targets

Authors:

Andreas Seeber, Rebecca Gruber, Florian Kocher, Kai Zimmer, Alberto Puccini, Harris Krause, Daniel Neureiter, Eckhard Klieser, Stefan Salcher, Agnieszka Martowicz, Emil Lou, Wafik El-Deiry, Elisa Fontana, Pat Gulhati, Moh’d Khushman, Dominic Fong, Heinz-Josef Lenz, Domink Wolf, Matthew Oberley, Viktorija Sokolova

Conclusions

  • This is the first study comprehensively mapping XPO1 mRNA expression and immune-correlates in PDAC.
  • We found that high XPO1 is linked to increased immune cell infiltration and more T cell-inflamed tumors.
  • Our data provides a potential rationale to combine immune checkpoint therapy (+/- XPO1 inhibitors) in XPO1H PDACs.
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