Prevalence and Prognosis of ER-Loss in Advanced Invasive Lobular Carcinoma | Caris Life Sciences
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Prevalence and Prognosis of ER-Loss in Advanced Invasive Lobular Carcinoma

– Caris Life Sciences

Poster

Key Findings:

  • In a large real-word dataset, ER-loss likely occurred in 11.4% of invasive lobular carcinoma (ILC).
  • ER-loss in ILC was associated with worse overall survival compared to ER-loss in invasive ductal carcinoma and ILC without ER-loss.
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  • Structurally-oriented classification of FOXA1 alterations identifies prostate cancers with opposing clinical outcomes and distinct molecular and immunologic subtypes 

    – Caris Life Sciences

    Manuscript

    Abstract Purpose: 10-15% of prostate cancers (PCa) harbor recurrent FOXA1 aberrations whereby the alteration type and the effect on the forkhead( FKH) domain impacts protein-function. We developed… […]

  • Spliceosome Mutations in Metastatic Breast Cancer An Analysis of a Decentralized Clinical Trial and Large Clinical Genomic Dataset

    – Caris Life Sciences

    Poster

    […]
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