Molecular Characterization of Bladder Cancer in Smokers versus Nonsmokers

Authors:

Monika Joshi, MD, MRCP, Sherri Z. Millis, MS, PhD, Donald Lamm, MD, Sandeep Reddy, MD, Sheldon L. Holder, MD, PhD, Nicholas J. Vogelzang, MD, Joseph J. Drabick, MD

Background

  • Bladder cancer (BC) is one of the most common malignancies of the urinary tract and is the 4th most common cancer among men.
  • It is estimated that by the end of 2015, the US will have approximately 74,000 new BC cases, accounting for 16,000 cancer- related deaths.
  • Smoking is considered an important risk factor for BC. Recent data demonstrate an increase in BC incidence in nonsmokers as well.
  • Molecular characterization of BC in nonsmokers has not been wellstudied.

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