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Mutations on the homologous recombination pathway in 13 cancer types

– Caris Life Sciences

Poster

Background

The HR pathway is important in DNA double-strand break repair. HR defects promote carcinogenesis and are associated with selective sensitivity to PARP-inhibitors and DNA-damaging agents like platinum.

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  • Pan-sarcoma analysis of DNA damage response pathway alterations and deficiency

    – Caris Life Sciences

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    Key Finding: DNA damage repair pathway mutations are present in 25 of 38 pediatric and adult histologic subtypes of sarcoma.  […]

  • Actionable co-alterations in breast tumors with pathogenic mutations in the homologous recombination DNA damage repair pathway

    – Caris Life Sciences

    Poster

    INTRODUCTION AND PURPOSE Homologous recombination deficiency (HRD) is common in breast cancer, with somatic frequencies of 15.6% previously reported1. Targeted therapies including PARP inhibitors may… […]
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