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BRAF mutations are potentially targetable alterations in a wide variety of solid cancers

– Caris Life Sciences

Poster

Background

The BRAF gene mutations are potentially targetable with several treatment modalities approved in a limited number of cancer types. The present study explored the spectrum and frequencies of BRAF mutations in a wide variety of solid tumors.

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  • Association of class II and III BRAF mutations with EGFR blockade therapy response and representation of molecularly distinct subgroups of BRAF mutations in MMR proficient CRC

    – Caris Life Sciences

    Poster

    BRAF mutations represent a highly heterogeneous group of molecular alterations seen in colorectal cancer (CRC). Class I BRAF mutation (V600) render aggressive biology to CRC… […]

  • Resistance surveillance in a BRAF mutant melanoma patient on long term BRAF-inhibitor treatment

    – Caris Life Sciences

    Manuscript

    Abstract Treatment responses of BRAF mutant melanoma to BRAF inhibitors are often limited by the development of resistance. This case report describes the use of… […]
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